Therapeutic and prophylactic effects of some antibiotics on experimental pneumonic pasteurellosis

Pneumonic pasteurellosis was produced in cattle seronegative for bovine herpes virus-1 and Pasteurella haemolytica using their respective aerosols four days apart. When treated with four daily intravenous oxytetracycline injections one day prior, same day as and 24 hours after P. haemolytica aerosols cattle experienced a reduced mortality. Prophylactic sustained action antibiotics given 24 hours prior to the P. haemolytica aerosol also reduced mortality, however there appeared to be a variation associated with the products used.