Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone scanning: radionuclidic reaction mechanisms.

A G Jones, M D Francis, M A Davis

    Seminars in Nuclear Medicine
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Trends in Second-Line Initiations and Treatment Outcomes Across Age and Frailty Groups in People With Type 2 Diabetes: UK Population-Based Study, 2019-2024.

    Diabetes, obesity & metabolism·2026
    Same author

    Association between Family Household Income and Cognitive Resilience among Older US Adults: A Cross-Sectional Study.

    The journal of prevention of Alzheimer's disease·2024
    Same author

    US Adults' Likelihood to Participate in Dementia Prevention Drug Trials: Results from the National Poll on Healthy Aging.

    The journal of prevention of Alzheimer's disease·2023
    Same author

    Is glycaemic control associated with dietary patterns independent of weight change in people newly diagnosed with type 2 diabetes? Prospective analysis of the Early-ACTivity-In-Diabetes trial.

    BMC medicine·2022
    Same author

    Data to identify key drivers of animal growth and carcass quality for temperate lowland sheep production systems.

    Data in brief·2021
    Same author

    Using a lamb's early-life liveweight as a predictor of carcass quality.

    Animal : an international journal of animal bioscience·2021
    Same journal

    Letter from the Editors.

    Seminars in nuclear medicine·2026
    Same journal

    Expanding Horizons: The Role of Kaleidoscope and Relevant Images in Seminars in Nuclear Medicine.

    Seminars in nuclear medicine·2026
    Same journal

    The diagnostic performance and clinical value of [18F]FDG PET/CT in pleural mesothelioma - A systematic review and meta-analysis.

    Seminars in nuclear medicine·2026
    Same journal

    Feasibility of treating neuroendocrine prostate cancer with anti-SSTR radioligands: A systematic review of imaging and treatment studies.

    Seminars in nuclear medicine·2026
    Same journal

    <sup>18</sup>F-FDG -PET/CT in cardiac sarcoidosis: Diagnosis, therapy monitoring, and future directions.

    Seminars in nuclear medicine·2026
    Same journal

    Maximizing diagnostic yield: A systematic review and deep dive into PSMA PET scan protocol variations for prostate cancer.

    Seminars in nuclear medicine·2026
    See all related articles

    Technetium-99m bone-imaging agents are vital in nuclear medicine. This review examines the evidence for how these radiopharmaceuticals accumulate in skeletal sites.

    Area of Science:

    • Nuclear Medicine
    • Radiopharmaceutical Chemistry
    • Skeletal Imaging

    Background:

    • Technetium-99m (99mTc)-labeled bone-imaging agents represent a significant advancement in nuclear medicine.
    • Their clinical utility is well-established for diagnosing various skeletal conditions.

    Purpose of the Study:

    • To review the available evidence on the localization mechanisms of 99mTc-labeled bone agents.
    • To explore how these radiopharmaceuticals target specific sites within the skeleton.

    Main Methods:

    • Literature review of studies investigating radiopharmaceutical localization in bone.
    • Analysis of experimental and clinical data on bone-seeking tracers.
    • Examination of the physicochemical properties influencing skeletal uptake.

    Related Experiment Videos

    Main Results:

    • Multiple mechanisms contribute to the localization of 99mTc-bone agents, including bone surface deposition and cellular interactions.
    • The distribution is influenced by blood flow, bone metabolism, and the specific chelation of 99mTc.
    • Understanding these mechanisms is crucial for optimizing diagnostic accuracy.

    Conclusions:

    • The precise mechanisms of 99mTc-labeled bone agent localization are multifactorial.
    • Further research into these mechanisms can enhance the efficacy of skeletal imaging in nuclear medicine.