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Clostridium perfringens Type C Enterotoxemia.

The Canadian Veterinary Journal = La Revue Veterinaire Canadienne

|August 1, 1988

Summary

Clostridium perfringens type C causes fatal enteric disease in many animal species and humans, particularly newborns. Vaccination of the dam is an effective control method for this toxemia.

Area of Science:

Veterinary Medicine
Microbiology
Animal Health

Background:

Clostridium perfringens type C causes severe enteric disease in various animal species and humans.
Newborn animals exhibit heightened susceptibility due to factors like bacterial colonization and digestive functions.
The pathogenesis involves beta toxin and bacterial cell adherence to the jejunal villi, leading to necrotic mucosa.

Purpose of the Study:

To critically review forms of enteric disease caused by Clostridium perfringens type C.
To emphasize practical aspects and recent research findings.
To highlight control strategies and potential research areas.

Main Methods:

Review of available data and research findings.
Analysis of pathogenesis mechanisms.

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Assessment of control strategies.

Main Results:

Clostridium perfringens type C infects more animal species fatally than other types.
Fatal cases are documented in pigs, cattle, sheep, horses, and humans.
Death results from toxemia, despite intestinal lesions.

Conclusions:

Clostridium perfringens type C infection is a significant threat to animal and human health.
Vaccination of the dam is an effective preventive measure.
Further research into the epizootiology of this disease is warranted.