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Updated: Oct 12, 2026

Basics of Multivariate Analysis in Neuroimaging Data
Published on: July 24, 2010
Unbiased measures of transmitted information and channel capacity from multivariate neuronal data
L M Optican1, T J Gawne, B J Richmond
1Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, Md.
Abstract:
Two measures from information theory, transmitted information and channel capacity, can quantify the ability of neurons to convey stimulus-dependent information. These measures are calculated using probability functions estimated from stimulus-response data. However, these estimates are biased by response quantization, noise, and small sample sizes. Improved estimators are developed in this paper that depend on both an estimate of the sample-size bias and the noise in the data.
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