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[Changes of cognition and micronutrient levels in rats treated by beta amyloid protein]
1Institute of Hygiene and Environmental Medicine, Tianjin 300050, China. jyg1967@126.com
Objective:
To observe the changes of the cognition and micronutrient level in rats treated by beta amyloid protein.
Methods:
Thirty male Sprague-Dawley rats were randomly divided into control group, beta amyloid group (Abeta) and saline group. The rats were injected Abeta and saline by bilateral intrahippocampus (10 microg per lateral) in Abeta group and saline group separately. The experiment lasted 2 weeks.The cognition was identified by water maze and step through test. The contents of serum micronutrients were examined by atomic absorption spectrometry and fluorescence spectrometry.
Results:
Declined cognition and prolonged latency were observed in Abeta group. The contents of serum vitamin C and iron in Abeta group were significantly lower than those of the control group and saline group (P < 0.05). There was no significant difference among the three groups in other indicators.
Conclusion:
It was seemed that impaired cognition and decreases of serum vitamin C and iron level could be observed in rats treated by beta amyloid protein.
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