Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iron absorption in hypotransferrinemic mice.

S S Buys1, C B Martin, M Eldridge

  • 1Department of Medicine, University of Utah School of Medicine, Salt Lake City, 84132.

Blood
|December 15, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal Flow Decorrelations in Xe+Xe Collisions at sqrt[s_{NN}]=5.44  TeV with the ATLAS Detector.

Physical review letters·2021
Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson Decaying into W^{±}W^{∓} or ZZ in Fully Hadronic Final States from sqrt[s]=13  TeV pp Collisions Recorded with the ATLAS Detector.

Physical review letters·2021
Same author

Medium-Induced Modification of Z-Tagged Charged Particle Yields in Pb+Pb Collisions at 5.02 TeV with the ATLAS Detector.

Physical review letters·2021
Same author

Observation and Measurement of Forward Proton Scattering in Association with Lepton Pairs Produced via the Photon Fusion Mechanism at ATLAS.

Physical review letters·2021
Same author

Search for Heavy Resonances Decaying into a Photon and a Hadronically Decaying Higgs Boson in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2021
Same author

Search for Higgs Boson Decays into a Z Boson and a Light Hadronically Decaying Resonance Using 13 TeV pp Collision Data from the ATLAS Detector.

Physical review letters·2020
Same journal

Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.

Blood·2026
Same journal

Identifying steroid-refractory aGVHD before it happens.

Blood·2026
Same journal

ELISA-negative HIT: antibody recognition and relevance.

Blood·2026
Same journal

EBV and immunodeficiency: the odd couple drawn to the brain.

Blood·2026
Same journal

A bone to pick with ferric carboxymaltose.

Blood·2026
Same journal

A step toward streamlining HIT diagnosis.

Blood·2026
See all related articles

Transferrin (Tf) is not essential for gastrointestinal iron uptake. Studies using hypotransferrinemic mice show iron absorption remains high without Tf, suggesting no essential role for Tf in iron absorption regulation.

Area of Science:

  • Physiology
  • Hematology
  • Gastroenterology

Background:

  • Transferrin (Tf) is the primary iron-binding protein in plasma.
  • Its role in regulating gastrointestinal iron absorption is not fully understood.
  • Hypotransferrinemic (Htx) mice offer a unique model to study Tf's function.

Purpose of the Study:

  • To investigate the role of transferrin (Tf) in gastrointestinal iron absorption.
  • To determine if Tf acts as a carrier or a humoral regulator of iron uptake.
  • To identify potential humoral regulators of iron absorption.

Main Methods:

  • Utilized hypotransferrinemic (Htx) mice, which lack transferrin.
  • Administered red blood cell transfusions to Htx mice to normalize hematocrit and reticulocyte counts.

Related Experiment Videos

  • Performed plasma and whole blood transfers from Htx mice to normal mice.

    • Main Results:

    • Htx mice exhibited hyperabsorption of iron despite the absence of Tf.
    • Iron absorption normalized in Htx mice following red blood cell transfusion.
    • Plasma or blood transfer from iron-hyperabsorbing mice did not increase iron absorption in recipients.

    Conclusions:

    • Transferrin (Tf) is not an obligate factor in gastrointestinal iron absorption.
    • Tf does not function as a necessary carrier or humoral signal for iron uptake.
    • No evidence of a humoral regulator of gastrointestinal iron absorption was detected.