Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental gastric cancer.

H Ohgaki1, P Kleihues, T Sugimura

  • 1Institute of Pathology, University of Zürich, Switzerland.

The Italian Journal of Gastroenterology
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of x-ray bremsstrahlung radiation from high energy electrons by stochastic acceleration in Heliotron J.

The Review of scientific instruments·2025
Same author

Correction: Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma.

Oncogene·2022
Same author

Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma.

British journal of cancer·2013
Same author

Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity.

Neuropathology and applied neurobiology·2013
Same author

Persistence of alkylated DNA bases in the Mongolian gerbil (Meriones unguiculatus) following a single dose of methylnitrosourea +.

Carcinogenesis·2012
Same author

Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma.

Oncogene·2011
Same journal

Recent Advances on NSAID and NSAID Gastropathy, 1st annual meeting. Ferrara, Italy, 6-7 December 1996. Proceedings.

The Italian journal of gastroenterology·1996
Same journal

Irritable oesophagus syndrome as cause of chronic cough.

The Italian journal of gastroenterology·1996
Same journal

Small bowel tumours in Tuscany.

The Italian journal of gastroenterology·1996
Same journal

Prevalence of hepatitis E in a central Italian town at high endemicity for hepatitis C virus.

The Italian journal of gastroenterology·1996
Same journal

Stimulatory effect of (R) alpha-methylhistamine on duodenal HCO3- secretion in anaesthetized rats.

The Italian journal of gastroenterology·1996
Same journal

Delayed gastric emptying in an infant with Sandifer syndrome.

The Italian journal of gastroenterology·1996
See all related articles

Researchers explored chemical induction of gastric cancer using N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Factors like DNA methylation, species, and environment significantly influence gastric carcinogenesis and tumor development.

Area of Science:

  • Gastroenterology
  • Oncology
  • Toxicology

Background:

  • N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) are established chemical carcinogens for inducing gastric carcinomas.
  • Gastric carcinogenesis models vary in susceptibility, histologic outcomes, and biological behavior based on treatment, species, strain, and sex.

Purpose of the Study:

  • To investigate the mechanisms and influencing factors in MNNG-induced gastric carcinogenesis.
  • To understand the organ specificity of MNNG and its correlation with DNA methylation levels.

Main Methods:

  • Oral administration of MNNG in experimental animal models (rats).
  • Analysis of DNA methylation in target (stomach mucosa) and non-target tissues.
  • Evaluation of modifying factors such as bile reflux, bile acids, sodium chloride, and ulceration.

Related Experiment Videos

Main Results:

  • MNNG's organ specificity correlates with DNA methylation levels in the stomach mucosa.
  • Thiol-mediated acceleration of MNNG decomposition contributes to high methylated DNA bases in the stomach.
  • Experimental gastric carcinogenesis is significantly modified by host and environmental factors.

Conclusions:

  • Chemical induction of gastric cancer by MNNG is a complex process influenced by multiple factors.
  • DNA methylation and environmental agents play crucial roles in the development of gastric carcinomas.
  • Further research into these factors can inform strategies for cancer prevention and treatment.