Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

What is Genetic Engineering?

What is Genetic Engineering?

Bone Remodeling and Repair

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CRISPR Learns to Read the Epigenome.

The CRISPR journal·2026

Same author

Prediction of Mesenchymal Stromal Cell Immune Suppression Using Live Imaging in a Three-Dimensional Microfluidic Device.

ACS biomaterials science & engineering·2026

Same author

A microgel bone marrow model of mesenchymal stromal cell paracrine signaling supporting hematopoietic stem cell retention.

Acta biomaterialia·2026

Same author

Transcription factor collaboration enables precise T cell state engineering.

bioRxiv : the preprint server for biology·2026

Same author

Enhancer hubs govern chromatin topology and Th17 cell identity.

bioRxiv : the preprint server for biology·2026

Same author

Bone marrow-derived mesenchymal stromal cells yield greater pain relief and tissue protection than umbilical cord tissue-derived cells in a surgically induced instability model of osteoarthritis.

Osteoarthritis and cartilage·2026

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Genetic engineering for skeletal regenerative medicine.

Charles A Gersbach¹, Jennifer E Phillips, Andrés J García

¹Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Annual Review of Biomedical Engineering

|April 12, 2007

Summary

Genetic engineering and gene therapy offer promising solutions for skeletal tissue repair by enhancing cellular differentiation and matrix production. This review explores advances in gene carriers, cell sources, delivery, and target genes for bone and cartilage regeneration.

More Related Videos

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Published on: March 19, 2013

Related Experiment Videos

Last Updated: Jul 15, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Published on: March 19, 2013

Area of Science:

Biomedical Engineering
Regenerative Medicine
Molecular Biology

Background:

Clinical challenges in skeletal regenerative medicine drive innovation in tissue engineering.
Molecular biology advances enable gene-based strategies for skeletal tissue repair.
Genetic engineering is crucial for robust cellular differentiation and extracellular matrix production.

Purpose of the Study:

To review recent literature on genetic engineering for skeletal tissue regeneration.
To highlight advances in gene carriers, cell sources, delivery strategies, and target genes.
To discuss the current status and clinical challenges of gene-based skeletal repair.

Main Methods:

Literature review of genetic engineering applications in bone, cartilage, and connective tissue regeneration.
Analysis of advancements in gene delivery systems and cell sources.
Evaluation of target gene selection for enhanced skeletal repair.

Main Results:

Genetic engineering is a principal factor in effective tissue engineering for skeletal regeneration.
Significant progress has been made in developing efficacious gene carriers and delivery strategies.
Novel cell sources and optimal target genes are being identified for improved outcomes.

Conclusions:

Gene therapy is a conventional approach to enhance cellular activities for skeletal tissue repair.
Genetic engineering holds significant promise for bone, cartilage, and connective tissue regeneration.
Further research is needed to overcome challenges and achieve clinical realization of these approaches.