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Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
Published on: October 3, 2010
What is the best adjuvant treatment for very young patients with medulloblastoma?
James W Clarke1, Mersiha Hadziahmetovic, Katherine Tzou
1Ohio State University Medical Center, Department of Radiation Medicine, Arthur G James Cancer Hospital, Columbus, OH 43210, USA. james.clarke@osumc.edu
Abstract:
The standard treatment for medulloblastoma is surgery followed by adjuvant chemotherapy and external beam radiotherapy to the craniospinal axis and posterior fossa. However, in very young children, craniospinal irradiation has a more significant detrimental effect in terms of neurocognitive function and growth. This article reviews the different strategies used for very young patients with medulloblastoma.
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