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Related Experiment Video

Updated: Jul 15, 2026

Orthotopic Small Bowel Transplantation in Rats
09:16

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Published on: November 6, 2012

Steroids in intestinal transplantation.

A Dazzi1, A Lauro, C Zanfi

  • 1UO Chirurgia dei Trapianti di Fegato e Multiorgano, University of Bologna, Bologna, Italy.

Clinical Transplantation
|April 12, 2007
PubMed
Summary

High-dose steroids after intestinal transplantation did not improve survival and increased infections. Avoiding high-dose steroid maintenance therapy may enhance outcomes in transplant patients.

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Area of Science:

  • Transplantation immunology
  • Gastroenterology
  • Surgical oncology

Background:

  • New immunosuppressive protocols aim to reduce steroid use in intestinal transplantation.
  • Steroids carry adverse effects, prompting research into steroid-sparing strategies.

Purpose of the Study:

  • To evaluate the impact of steroid dosage on survival and complications after intestinal transplantation.
  • To analyze the correlation between steroid use and post-transplant outcomes.

Main Methods:

  • Retrospective study of 25 patients undergoing intestinal/multivisceral transplantation.
  • Analysis of mean daily steroid dosage, graft and patient survival, rejection, infections, and side effects.

Main Results:

  • High-dose prednisone (>20 mg/d) was associated with significantly lower graft and patient survival rates.
  • Increased frequency of infections was observed during steroid administration.
  • No significant difference in steroid doses was found between different immunosuppressive protocols.

Conclusions:

  • High-dose steroid regimens did not improve graft or patient survival post-intestinal transplantation.
  • Steroid therapy may be necessary for acute rejection but not as maintenance therapy.
  • Avoiding high-dose steroids as maintenance therapy could be beneficial, except in select cases.