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Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≄ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

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Multidisciplinary Approach to Obesity Management: A Case Report
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Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Randomized trial of a multifaceted commercial weight loss program.

Cheryl L Rock1, Bilge Pakiz, Shirley W Flatt

  • 1Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, Dept. 0901, La Jolla, CA 92093-0901, USA. clrock@ucsd.edu

Obesity (Silver Spring, Md.)
|April 12, 2007
PubMed
Summary

This study shows a commercial weight loss program effectively reduces weight and improves health markers like HDL cholesterol and insulin levels in overweight women. The weight loss was maintained for one year.

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Area of Science:

  • Obesity research
  • Nutritional science
  • Metabolic health

Background:

  • Overweight and obesity are significant public health concerns.
  • Effective and sustainable weight management strategies are needed.
  • Commercial weight loss programs offer accessible interventions.

Purpose of the Study:

  • To evaluate the efficacy of a commercial weight loss program.
  • To assess its impact on body weight and body composition.
  • To investigate effects on plasma lipids, hormones, and fitness levels.

Main Methods:

  • Randomized controlled trial with overweight or obese women.
  • Intervention group received a commercial weight loss program.
  • Control group received no intervention.

Main Results:

  • Significant weight loss (-7.2 kg, -7.8%) observed in the intervention group at 6 months (p<0.01).
  • Sustained weight loss and reduction in BMI and waist/hip circumference at 1 year.
  • Improved high-density lipoprotein (HDL) cholesterol and decreased fasting insulin levels in the intervention group.

Conclusions:

  • The commercial program effectively promotes significant and sustained weight loss.
  • The program positively influences key metabolic health indicators.
  • This intervention demonstrates a viable approach for managing overweight and obesity.