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High-content T-cell and B-cell analysis

Markus Maeurer1

  • 1Microbiology and Tumor Cell Biology Center and SMI, Nobels Väg 18, Karolinska Institutet, Stockholm, Sweden. markus.maeurer@smi.ki.se

Clinical Reviews in Allergy & Immunology
|April 12, 2007
PubMed

Immune responses are orchestrated by B- and T-cells endowed with a diverse repertoire of antigen receptors. Comprehensive profiling of the humoral and cellular immune responses, including molecular composition, the specificity of the response, the cellular activation, differentiation, and homing status, will aid to improve diagnosis, classification, monitoring, and prognostication of immune disorders driven by antigen-specific B- and T-lymphocytes.

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Naive T cells that have not yet encountered an antigen express two primary CD...