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Updated: Jul 15, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
A critical review of local anesthetic sensitivity
Eric Boren1, Suzanne S Teuber, Stanley M Naguwa
1Division of Rheumatology, Allergy, and Clinical Immunology, Department of Internal Medicine, University of California at Davis School of Medicine, Davis, CA, USA.
Abstract:
With their ability to block pain signals to the brain, local anesthetics (LAs) have made possible many surgical procedures and interventions once thought impossible. LAs are generally safe and well tolerated when used correctly by trained professionals. However, adverse reactions do occur, and may generate a referral to an Allergist for evaluation of LA allergy. LA structure, classification, and metabolism will be briefly reviewed. A critical analysis of the studies and case reports involving LA allergy found via PubMed search for "local anesthetic allergy" and "local anesthetic hypersensitivity" will be discussed. In addition, the clinical evaluation of a patient with concern for a LA allergy will be examined.
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