Related Experiment Video
Updated: Jul 15, 2026

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
Published on: April 6, 2016
Modelling and simulation of signal transductions in an apoptosis pathway by using timed Petri nets
Chen Li1, Qi-Wei Ge, Mitsuru Nakata
1Graduate School of Science and Engineering, Faculty of Education, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8511, Japan.
Abstract:
This paper first presents basic Petri net components representing molecular interactions and mechanisms of signalling pathways, and introduces a method to construct a Petri net model of a signalling pathway with these components. Then a simulation method of determining the delay time of transitions, by using timed Petri nets - i.e. the time taken in fi ring of each transition - is proposed based on some simple principles that the number of tokens flowed into a place is equivalent to the number of tokens fl owed out. Finally, the availability of proposed method is confirmed by observing signalling transductions in biological pathways through simulation experiments of the apoptosis signalling pathways as an example.
More Related Videos
Related Concept Videos
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Intracellular Signaling Cascades
The Extrinsic Apoptotic Pathway
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
MAPK Signaling Cascades
Cellular Injury V: Apoptosis and Autophagy

