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Updated: Jul 15, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

Argon plasma coagulation in chronic radiation proctitis.

A Postgate¹, B Saunders, J Tjandra

¹Wolfson Unit for Endoscopy, St. Mark's Hospital, London, UK. apostgate@yahoo.com

|April 12, 2007

Summary

Argon plasma coagulation (APC) effectively treats chronic radiation proctitis, reducing rectal bleeding in most patients. This endoscopic therapy offers a safe and well-tolerated option for managing radiation-induced rectal complications.

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Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells

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Published on: November 17, 2017

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Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells

Published on: November 17, 2017

Area of Science:

Gastroenterology
Oncology
Medical Technology

Background:

Chronic radiation proctitis is a common complication following pelvic irradiation.
Symptoms include diarrhea, urgency, tenesmus, and rectal bleeding, significantly impacting quality of life.
Severe cases of hemorrhagic radiation proctitis are challenging to manage with conventional medical therapies.

Purpose of the Study:

To evaluate the efficacy and safety of Argon Plasma Coagulation (APC) for treating chronic radiation proctitis.
To assess APC's impact on rectal bleeding and associated symptoms.

Main Methods:

Argon plasma coagulation (APC) is an endoscopic noncontact thermal coagulation technique.
APC utilizes ionized argon gas delivered via a probe to the mucosal surface, causing superficial heating and coagulation of friable vessels.
The procedure is performed endoscopically.

Main Results:

APC reduces rectal bleeding in 80%-90% of patients with chronic radiation proctitis.
The technique may also improve associated symptoms such as diarrhea and urgency.
APC is generally safe and well-tolerated, though potentially less effective in the most severe hemorrhagic cases.

Conclusions:

Argon plasma coagulation is an effective and safe endoscopic treatment for chronic radiation proctitis.
For severe hemorrhagic cases, topical formalin or a combination therapy may be considered.
APC offers a valuable therapeutic option for managing radiation-induced proctitis.