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Incidence of antibiotic-associated diarrhea in a pediatric ambulatory care setting

Alisara Damrongmanee1, Nuthapong Ukarapol

  • 1Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|April 13, 2007
PubMed

Insights

Antibiotic-associated diarrhea (AAD) affected 6.2% of children in a pediatric outpatient setting. While not statistically significant, amoxicillin/clavulanate showed a trend toward higher AAD incidence, particularly in younger children.

Area of Science:

  • Pediatric infectious diseases
  • Clinical pharmacology
  • Gastroenterology

Background:

  • Antibiotic-associated diarrhea (AAD) is a frequent adverse event in pediatric patients receiving oral antibiotics.
  • Limited epidemiological data exist regarding the incidence and risk factors of AAD in children.

Purpose of the Study:

  • To determine the incidence of antibiotic-associated diarrhea (AAD) in children treated with oral antibiotics.
  • To identify potential risk factors associated with AAD in a pediatric outpatient setting.

Main Methods:

  • Prospective study enrolling 225 children prescribed oral antibiotics.
  • Exclusion criteria included immunodeficiency, existing diarrhea, and recent antibiotic use.
  • AAD defined as ≥3 loose stools/day for 2 consecutive days; data collected via parental questionnaire.

Main Results:

  • The incidence of AAD was 6.2% among the study population.
  • Pharyngotonsillitis was the most common diagnosis; amoxicillin and cloxacillin were frequently prescribed.
  • A trend towards higher AAD incidence was observed with amoxicillin/clavulanate, though not statistically significant.

Conclusions:

  • Antibiotic-associated diarrhea (AAD) is a notable concern in pediatric ambulatory care.
  • Younger children receiving amoxicillin/clavulanate may have an increased risk of developing AAD.
Abstract

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