Related Experiment Video
Updated: Jul 15, 2026
13:10
Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
Published on: May 15, 2013
Volatile organic compounds contribute to airway hyperresponsiveness.
An-Soo Jang1, Inseon-S Choi, Young-Il Koh
1Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, Korea.
The Korean Journal of Internal Medicine
|April 13, 2007
Summary
Exposure to volatile organic compounds (VOCs) may increase airway hyperresponsiveness in workers. This study found higher airway responsiveness in VOC-exposed workers, particularly those with atopy or who smoke.
Area of Science:
- Occupational Health
- Environmental Health
- Pulmonology
Background:
- Volatile organic compounds (VOCs) are prevalent in work and home environments.
- VOC exposure may impact lung function and airway responsiveness.
Purpose of the Study:
- Investigate the prevalence of airway responsiveness in workers exposed to VOCs.
- Determine if VOC exposure is associated with increased airway hyperresponsiveness.
Main Methods:
- Employed allergic skin tests, airway hyperresponsiveness testing (BRindex), and questionnaires.
- Studied 20 VOC-exposed workers and 27 control subjects.
- Defined atopy and airway hyperresponsiveness using established criteria.
Main Results:
- VOC-exposed workers showed a trend towards higher airway hyperresponsiveness (BRindex) compared to controls.
- Workers with atopy or smoking status exhibited significantly higher BRindex values.
- No correlation found between BRindex and atopy, smoking, or duration of VOC exposure.
Conclusions:
- Findings suggest VOCs may contribute to airway hyperresponsiveness in occupational settings.
- VOC exposure is a potential risk factor for developing airway hyperresponsiveness.
- Further research is warranted to elucidate the mechanisms of VOCs on respiratory health.
Related Concept Videos
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:19Factors Affecting Pulmonary Ventilation
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...