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A note on the action of glutamine on cortical spreading depression
P de A Maranhão-Filho1, A A Leão
1Neurology Service, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil.
Cephalalgia : an International Journal of Headache
|September 1, 1991
Abstract:
Application of a solution of 1-glutamine, 75 mM, to the pia-arachnoid surface of the dorsolateral neocortex of rabbits under dial-urethane anaesthesia was found to reversibly render the tissue insusceptible to spreading depression. It is suggested that this amide may play a part in the opposition normally offered by the tissue to undergo spreading depression. Some evidence is adduced which seems to support this suggestion.