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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

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Published on: March 17, 2020

Blastomycosis in solid organ transplant recipients.

G M Gauthier¹, N Safdar, B S Klein

¹Department of Internal Medicine, Section of Infectious Diseases, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA.

Transplant Infectious Disease : an Official Journal of the Transplantation Society

|April 13, 2007

Summary

Blastomycosis is an uncommon infection in solid organ transplant recipients, often presenting as pneumonia and complicated by acute respiratory distress syndrome (ARDS). Lifelong antifungal therapy may not be necessary after successful treatment.

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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Area of Science:

Mycology
Infectious Diseases
Transplantation Medicine

Background:

Blastomyces dermatitidis causes severe blastomycosis in immunocompromised individuals.
Limited data exists on blastomycosis in solid organ transplant (SOT) recipients.

Purpose of the Study:

To describe the epidemiology, clinical features, and outcomes of blastomycosis in SOT recipients.

Main Methods:

Retrospective case-series at the University of Wisconsin Hospital and Clinics.
Included SOT recipients diagnosed with blastomycosis between 1986 and 2004.

Main Results:

11 cases identified; 64% occurred between 2000-2004.
Median onset 26 months post-transplant; pneumonia common, often with ARDS.
36% mortality, rising to 67% with ARDS; extrapulmonary disease involved skin, not CNS.

Conclusions:

Blastomycosis is an uncommon but serious SOT complication.
Frequent complications include ARDS, dissemination, and co-infections.
Lifelong antifungal suppression may not be required post-cure.