Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelium and regulatory cell interactions.

C O S Savage1

  • 1Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham, UK. c.o.s.savage@bham.ac.uk

Clinical and Experimental Rheumatology
|April 13, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process.

Annals of the rheumatic diseases·2011
Same author

Pathogenesis of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis.

Clinical and experimental immunology·2011
Same author

Impact of compound heterozygous complement factor H mutations on development of atypical hemolytic uremic syndrome-A pedigree revisited.

Molecular immunology·2010
Same author

ANCA-associated vasculitides: advances in pathophysiology and treatment.

The Netherlands journal of medicine·2010
Same author

The role of the endothelium in systemic small vessel vasculitis.

Clinical and experimental rheumatology·2008
Same author

Mannose-binding lectin gene polymorphisms in a cohort study of ANCA-associated small vessel vasculitis.

Rheumatology (Oxford, England)·2007
Same journal

The expanded cardiovascular risk prediction score as a cardiovascular mortality predictor in rheumatoid arthritis.

Clinical and experimental rheumatology·2026
Same journal

Rising overweight and obesity in Swiss psoriatic arthritis patients, 2007-2022: a nationwide registry-population comparison.

Clinical and experimental rheumatology·2026
Same journal

Clinical features and gastrointestinal bleeding risk factors in IgA vasculitis patients: a retrospective study in a large volume centre.

Clinical and experimental rheumatology·2026
Same journal

Reply to the comment on: The microbiota in axial spondyloarthritis: what have we learned from Mendelian randomisation studies?

Clinical and experimental rheumatology·2026
Same journal

Comprehensive evaluation of bone structural and microarchitectural changes in rheumatoid arthritis treated with baricitinib using HR-pQCT, imaging, and biomarker analyses.

Clinical and experimental rheumatology·2026
Same journal

Tracking interstitial lung disease in systemic sclerosis: integrating lung magnetic resonance imaging into a clinically oriented multimodal follow-up strategy.

Clinical and experimental rheumatology·2026
See all related articles

Endothelial cells, crucial for blood vessel health, can regulate their own survival. This self-regulation impacts how susceptible these cells are to injury in various vascular conditions like vasculitis.

Area of Science:

  • Vascular Biology
  • Cellular Biology
  • Pathology

Background:

  • Endothelial cells form the inner lining of blood vessels and are susceptible to injury in diseases such as vasculitis.
  • Recent research highlights the intrinsic capacity of endothelial cells to influence their own survival and response to damage.
  • Understanding these mechanisms is key to addressing vascular pathologies.

Purpose of the Study:

  • To explore the self-regulatory mechanisms of endothelial cells concerning their fate.
  • To investigate how these intrinsic abilities affect endothelial cell injury susceptibility across different vascular beds.

Main Methods:

  • Review of current literature on endothelial cell biology and injury responses.
  • Analysis of studies investigating endothelial cell survival pathways.

Related Experiment Videos

  • Comparative assessment of endothelial cell vulnerability in distinct vascular environments.

    • Main Results:

    • Endothelial cells possess inherent pathways that modulate their survival and resistance to injury.
    • The expression and activity of these pathways vary significantly between different types of vascular beds.
    • This intrinsic variability influences the differential susceptibility of endothelial cells to injury in various diseases.

    Conclusions:

    • Endothelial cell self-fate regulation is a critical factor in determining injury susceptibility.
    • Therapeutic strategies targeting these pathways could offer new avenues for treating vascular diseases.
    • Further research into vascular bed-specific differences is warranted to develop targeted treatments.