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[Expression of Langerhans cell-related chemokine genes in condyloma acuminatum epidermis]
Jin-Yun Feng1, Zhen-Hui Peng, Guo-Zhou Rao
1Department of Dermatology, the Second Hospital, Xi'an Jiaotong University, Xi'an 710004, China. fjyfjy888@163.com
Aim:
To investigate differential gene expression of Langerhans cell-related chemokines in condyloma acuminatum (CA) epidermis and normal epidermis.
Methods:
Gene expression of Langerhans cell-related chemokines in three CA epidermal lesions and in three normal controls was screened using Affymetrix oligonucleotide microarrays HG-U 133A 2.0, and part of the above differential gene expression was confirmed by semi-quantitative RT-PCR.
Results:
With microarrays, seven down-regulated genes of Langerhans cell-related chemokine were detected in three CA epidermal lesions as compared with three normal controls, and the down-regulation of CXCR4 and CCL20 was verified by semi-quantitative RT-PCR.
Conclusion:
Several Langerhans cell-related chemokine genes are found down-regulated in CA epidermis as compared with normal epidermis, and the down-regulation of these genes may contribute to the decreased number and the homing disturbance of LC in CA epidermis.