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Updated: Jul 15, 2026

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
Published on: June 28, 2019
Endometrial carcinoma first presenting as paraneoplastic cerebellar degeneration
Yair Erez1, Nathan Rojansky, David Shveiky
1Department of Obstetrics and Gynecology, Hadassah Medical Center, Ein-Kerem, Jerusalem, IL POB 12000, Israel. erezyair@gmail.com
Background:
Paraneoplastic degeneration (PCD) is an immune-mediated disorder affecting the cerebellum, characterized by subacute onset of cerebellar dysfunction progressing to severe disability, and is associated with an underlying malignancy. Ovarian carcinoma and breast carcinoma are commonly implicated.
Case:
We report a rare case PCD in an elderly woman, later diagnosed with endometrial carcinoma.
Conclusion:
PCD is an unusual and rare manifestation of gynecological malignancies, including endometrial carcinoma, and a high degree of suspicion is required in these cases in order to make the correct diagnosis.
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