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Overexpression of HFE in HepG2 cells reveals differences in intracellular distribution and co-localization of wt- and

Jorge P Pinto1, Pedro Ramos, Maria de Sousa

  • 1Iron Genes and Immune System, IBMC, Instituto de Biologia Molecular e Celular, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.

Blood Cells, Molecules & Diseases
|April 13, 2007
PubMed

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After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
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