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Related Experiment Videos

The lipid-binding SEC14 domain.

Kan Saito1, Lutz Tautz, Tomas Mustelin

  • 1The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Biochimica Et Biophysica Acta
|April 13, 2007
PubMed
Summary
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This review explores the SEC14 (also known as CRAL_TRIO) domain, crucial for protein-lipid interactions in cellular processes like signal transduction and membrane maintenance. It summarizes existing research and new findings on this important lipid-binding domain.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Protein-lipid interactions are fundamental to numerous cellular processes, including signal transduction, lipid transport, and membrane integrity.
  • Specific protein domains, such as PH, FYVE, PX, PHD, C2, and SEC14 homology domains, are responsible for mediating these interactions with phospholipids.
  • The SEC14 homology (CRAL_TRIO) domain is a key player in recognizing and binding specific lipids, influencing cellular functions.

Purpose of the Study:

  • To provide a comprehensive review of the biological significance of the SEC14 (CRAL_TRIO) domain.
  • To consolidate published literature and present recent unpublished findings related to the SEC14 domain.
  • To highlight the role of the SEC14 domain in protein-lipid interactions and cellular mechanisms.

Main Methods:

Related Experiment Videos

  • Literature review of published research on SEC14 domain biology.
  • Inclusion of recent unpublished experimental findings.
  • Analysis of the structural and functional roles of the SEC14 domain in protein-lipid interactions.

Main Results:

  • The SEC14 domain, also known as CRAL_TRIO, is a critical lipid-binding module.
  • This domain mediates essential protein-lipid interactions involved in cellular functions.
  • The review synthesizes current knowledge and introduces novel insights into SEC14 domain biology.

Conclusions:

  • The SEC14 (CRAL_TRIO) domain plays a vital role in cellular processes through specific protein-lipid interactions.
  • Understanding the biology of the SEC14 domain is crucial for deciphering complex cellular mechanisms.
  • Further research into the SEC14 domain promises to uncover new therapeutic targets and biological insights.