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Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Imbalances in Cardiac Output01:26

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Regulation of Stroke Volume01:27

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Related Experiment Video

Updated: Jul 15, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

The effect of collateral circulation on left ventricular systolic function.

Filiz Karadas1, Kenan Yalta, Okan Onur Turgut

  • 1Department of Cardiology, Cumhuriyet University, Sivas, Turkey.

Coronary Artery Disease
|April 13, 2007
PubMed
Summary

Coronary collateral circulation in severe left anterior descending artery stenosis does not improve left ventricular systolic function. Instead, it is associated with impaired function and worse outcomes.

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Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Last Updated: Jul 15, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

Area of Science:

  • Cardiology
  • Vascular Biology
  • Cardiac Function

Background:

  • Conflicting evidence exists regarding the role of coronary collateral circulation in preserving left ventricular systolic function.
  • This study investigates the impact of coronary collateral circulation on left ventricular systolic function in patients with coronary artery disease.

Purpose of the Study:

  • To assess the effect of coronary collateral circulation on left ventricular systolic function in patients with coronary artery disease.

Main Methods:

  • Seventy-one patients with severe (>=95%) stenosis of the left anterior descending artery were included.
  • Coronary collateral circulation was evaluated, and its relationship with left ventricular systolic function was analyzed.

Main Results:

  • Patients with coronary collateral circulation (grade >=1) showed higher left ventricular function scores but lower ejection fractions compared to those without (grade 0).
  • Coronary collateral circulation grade positively correlated with left ventricular function score and negatively with ejection fraction.
  • The presence and grade of coronary collateral circulation were associated with impaired left ventricular systolic function.

Conclusions:

  • Coronary collateral circulation does not improve, but rather impairs, left ventricular systolic function in severe left anterior descending artery stenosis.
  • The findings contradict previous studies and suggest an association between collateral circulation and systolic dysfunction.
  • Further research with larger cohorts and long-term follow-up is needed to elucidate this complex relationship.