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Transforming growth factor beta1 up-regulates interferon regulatory factor 8 during dendritic cell development

Xin-Sheng Ju1, David Ruau, Piritta Jäntti

  • 1Institute for Biomedical Engineering, Department of Cell Biology, Aachen University Hospital, Aachen, Germany.

European Journal of Immunology
|April 13, 2007
PubMed
Summary

Transforming growth factor beta1 (TGF-beta1) signaling directly regulates interferon regulatory factor 8 (IRF-8) in dendritic cells (DC). This pathway impacts DC function and migration by influencing CCR7 expression.

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