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Related Experiment Video

Updated: Jul 15, 2026

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

Published on: May 16, 2015

Why do ALTE infants not die in SIDS?

Ann Edner¹, Maria Wennborg, Bernt Alm

¹Department of Woman and Child, Astrid Lindgren Children's Hospital, SE-171 76 Stockholm, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)

|April 13, 2007

Summary

Sudden Infant Death Syndrome (SIDS) risk factors were compared in infants experiencing apparent life-threatening events (ALTE). Prone sleeping and maternal smoking were more common in ALTE infants who died of SIDS, suggesting distinct risk profiles.

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Area of Science:

Pediatrics
Neonatology
Public Health

Background:

Sudden Infant Death Syndrome (SIDS) and apparent life-threatening events (ALTE) are critical concerns in infant mortality.
Understanding risk factors is crucial for differentiating these conditions and informing prevention strategies.
Previous research has suggested potential links between ALTE and SIDS, necessitating further investigation.

Purpose of the Study:

To compare known risk factors for SIDS in infants with ALTE against matched controls.
To analyze differences between ALTE infants who died of SIDS and those who survived.

Main Methods:

Utilized questionnaire data from 58 infants with ALTE and 56 matched controls.
Included 244 SIDS cases and 868 SIDS control infants for comparison.
Analyzed risk factors including sleeping position and maternal smoking habits.

Main Results:

The incidence of ALTE was significantly higher in infants who later died of SIDS (7.4%) compared to SIDS controls (1.9%).
ALTE infants who died of SIDS showed a higher prevalence of prone sleeping and maternal smoking (33.3%) than survivors (13.3%).
No significant differences were found between ALTE infants and their matched controls regarding risk factors.

Conclusions:

Findings suggest that ALTE and SIDS may not represent the same underlying condition due to observed differences in risk factors.
A subgroup of ALTE infants might be protected from SIDS by back sleeping and avoidance of nicotine exposure.
Further research is needed to elucidate the relationship and potential shared risk factors between ALTE and SIDS.