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Pharmaceutical approaches to preparing pelletized dosage forms using the extrusion-spheronization process.

Namrata R Trivedi¹, Maria Gerald Rajan, James R Johnson

¹Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 26 South Dunlap Street, Memphis, TN 38163, USA.

Critical Reviews in Therapeutic Drug Carrier Systems

|April 14, 2007

Summary

This review explores recent advancements in preparing pelletized dosage forms using extrusion-spheronization. It details the process, formulation effects, and various pharmaceutical approaches for controlled drug delivery.

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Area of Science:

Pharmaceutical Technology
Drug Delivery Systems

Background:

Pelletized dosage forms offer advantages like improved flow, dissolution, and controlled drug release.
Various manufacturing techniques exist, including extrusion-spheronization.

Purpose of the Study:

To review recent pharmaceutical developments in pelletized dosage form preparation.
Focus on the extrusion-spheronization process over the last decade.

Main Methods:

Discussion of the extrusion-spheronization process.
Analysis of formulation and process parameter effects on pellet properties.
Overview of different preparation approaches using extrusion-spheronization.

Main Results:

Extrusion-spheronization is a key technique for producing spherical pellets.
Formulation and process parameters significantly influence pellet characteristics.
Diverse strategies have been developed for pellet preparation via this method.

Conclusions:

The extrusion-spheronization process has seen significant advancements.
This technique offers versatile applications for developing advanced pelletized drug delivery systems.
Further research continues to optimize pellet properties for enhanced therapeutic outcomes.