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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Asepsis01:28

Asepsis

The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

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Related Experiment Video

Updated: Jul 15, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Sepsis and solid organ transplantation.

A C Kalil1, H Dakroub, A G Freifeld

  • 1Section of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE 68198-5400, USA. akalil@unmc.edu

Current Drug Targets
|April 14, 2007
PubMed
Summary

Sepsis is a major threat to solid organ transplant (SOT) recipients, often lacking typical symptoms. Early diagnosis and tailored treatment are crucial for improving survival in these vulnerable patients.

Area of Science:

  • Transplantation Medicine
  • Infectious Diseases
  • Critical Care

Background:

  • Sepsis is a leading cause of mortality in solid organ transplantation (SOT) recipients.
  • Transplant recipients may not exhibit classic Systemic Inflammatory Response Syndrome (SIRS) criteria, complicating early sepsis diagnosis.
  • Understanding allograft-specific risks and surgical techniques is vital for managing infections in SOT patients.

Purpose of the Study:

  • To highlight the critical need for rapid sepsis diagnosis and treatment in SOT recipients.
  • To emphasize recognizing allograft-specific risk factors and surgical influences on infection presentation.
  • To discuss current approaches and recent developments in managing severe sepsis within the transplant population.

Main Methods:

  • Review of current literature and clinical practices regarding sepsis in SOT patients.

More Related Videos

Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

Related Experiment Videos

Last Updated: Jul 15, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

  • Analysis of the correlation between transplantation surgical techniques and infection manifestations.
  • Discussion of diagnostic and therapeutic strategies tailored for SOT recipients.

    • Main Results:

    • Sepsis diagnosis in SOT patients requires awareness of atypical presentations, differing from immunocompetent individuals.
    • Allograft type and specific surgical procedures influence infection risk and clinical signs.
    • Current management focuses on early detection, prompt antibiotic administration, surgical intervention if needed, and immunosuppression adjustment.

    Conclusions:

    • Precocious diagnosis and rapid intervention are key to improving sepsis outcomes in SOT patients.
    • Personalized approaches considering allograft type and surgical history are essential.
    • Ongoing research and adaptation of severe sepsis protocols are necessary for this unique patient group.