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Updated: Jul 15, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Effect of extending the platelet storage time on platelet utilization: predictions from a mathematical model of
1Service of Haemotherapy and Haemostasis, Hospital Clínic, Barcelona, Spain. apereira@clinic.ub.es
Insights
Extending platelet (PLT) storage using bacterial culturing (BCU) or photochemical treatment (PCT) increases PLT transfusions. This intensive usage may paradoxically lead to more time with low platelet counts, especially in complex patient cases.
Area of Science:
- Transfusion Medicine
- Hematology
- Biotechnology
Background:
- Extending platelet concentrate shelf-life is desirable for inventory management.
- Bacterial culturing (BCU) and photochemical treatment (PCT) are methods to extend platelet storage to 7 days.
- These methods may reduce post-transfusion platelet viability and recovery.
Purpose of the Study:
- To predict the impact of extended platelet shelf-life on the management of patients receiving prophylactic platelet support.
- To model the dynamics of platelet support under different storage conditions.
Main Methods:
- A mathematical model simulating prophylactic platelet support was developed.
- Data on post-transfusion platelet kinetics and treatment effects were sourced from published literature.
- Key variables included transfusion timing, PCT use, and synergistic effects on platelet consumption.
Main Results:
- Extending shelf-life to 7 days increased platelet transfusions by 9% (BCU) and 19% (PCT) in the reference scenario.
- In worst-case scenarios, increases reached 27% (BCU) and 38% (PCT).
- Despite increased usage, time spent with platelet counts below 10 x 10(9)/L often increased.
Conclusions:
- Extending platelet shelf-life significantly increases overall platelet usage.
- Potential synergistic interactions between extended storage/PCT and clinical factors may disproportionately increase usage in complex patients.
- Further clinical research is needed to understand these interactions and optimize patient management.
Abstract:
Bacterial culturing (BCU) or photochemical treatment (PCT) of platelet (PLT) concentrates may permit extending the storage time to 7 days at the cost of decreased viability of transfused PLTs. This study was aimed at predicting the impact this may have on the routine management of patients on prophylactic PLT support. The method included a mathematical model that represents the dynamics of prophylactic PLT support with standard, BCU or PCT PLTs. Data on posttransfusion PLT kinetics and the effect of PCT or storage time on PLT recovery and survival were obtained from published studies. Variables that influenced the level of PLT usage were the proportion of transfusions supplied with PLT on the last day of shelf-life, the use of PCT and the assumed degree of synergy between clinical factors of PLT consumption and either PCT or storage time. In the reference-case scenario, extending the PLT shelf-life to 7 days by BCU or PCT increased by 9 and 19%, respectively, the number of PLT transfusions per patient-year. In the worst-case scenario, these figures rose to 27 and 38%, respectively. Despite more intensive PLT usage, in most scenarios, the time that patients spent at PLT counts <10 x 10(9) L(-1) increased. Extending the shelf-life of PLT products will increase PLT usage. Such increase may be disproportionately larger for patients with complex conditions if there is a synergic interaction between storage time or PCT and clinical factors of PLT consumption, an issue that is worth further clinical research.
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