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Updated: Jul 15, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
New antiretroviral agents
Lawrence Siegel1, Roy M Gulick
1Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, Box 566, 525 East 68th Street, New York, NY 10021, USA.
Abstract:
Despite advances in HIV treatment and the availability of 22 approved antiretroviral drugs, newer compounds are needed that are better tolerated, less toxic, more convenient, or have improved activity against drug-resistant viruses. In addition to newer agents in development in traditional antiretroviral classes (reverse transcriptase inhibitors, protease inhibitors), a number of compounds in newer mechanistic classes also are under development, including entry inhibitors, integrase inhibitors, and maturation inhibitors. This review focuses on some of the investigational antiretroviral compounds that have reached clinical development and that offer the most promise for treatment of HIV-infected individuals.
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