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Related Experiment Videos

Systemic strategies for prostate cancer.

A J Armstrong1, P G Febbo, D J George

  • 1Duke Prostate Center, Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC, USA. andrew.armstrong@duke.edu

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology
|April 14, 2007
PubMed
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Systemic therapies beyond hormonal therapy are crucial for advanced prostate cancer. Research is evaluating chemotherapy and other agents in early and late disease stages to improve cure rates.

Area of Science:

  • Urologic Oncology
  • Medical Oncology

Background:

  • Hormonal therapy is standard for advanced prostate cancer.
  • Systemic therapies including chemotherapy are gaining acceptance for hormone-refractory disease.

Purpose of the Study:

  • To review the state of systemic therapy for advanced prostate cancer in 2007.
  • To emphasize agents in phase II and III trials impacting the standard of care.

Main Methods:

  • Review of current systemic therapies for advanced prostate cancer.
  • Emphasis on neoadjuvant, adjuvant, and metastatic settings.
  • Focus on agents in ongoing phase II and III clinical trials.

Main Results:

  • Chemotherapy acceptance is increasing for hormone-refractory prostate cancer.

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  • Ongoing trials aim to define the role of systemic therapy in earlier disease states.
  • Biomarker identification is crucial for predicting treatment sensitivity.
  • Conclusions:

    • Systemic therapies beyond hormonal therapy hold promise for advanced prostate cancer.
    • Clinical trials are essential for advancing prostate cancer management.
    • Personalized treatment approaches based on biomarkers are anticipated.