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Published on: January 23, 2026
[Subcutaneous emphysema of unusual extent]
S Besier1, T M Bingold, F Walcher
1Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe-Universität, 60596, Frankfurt am Main. s.besier@em.uni-frankfurt.de
Abstract:
Streptococcus agalactiae, known as a pathogen that causes meningitis and septicemia in neonates, emerges as an invasive organism in nonpregnant adults. This case report describes the fulminant course of a necrotizing fasciitis (NF) with streptococcal toxic shock-like syndrome (STSS) in a 76-year-old diabetic patient caused by S. agalactiae, serotype V. Chronic diseases and immunodeficiency are considered to be risk factors for the acquisition of group B streptococcal disease. Since early surgical treatment in conjunction with antimicrobial and intensive care therapy is critical for the outcome of patients with NF and/or STSS, clinicians should be aware of invasive S. agalactiae infections in adults with subcutaneous emphysema.
Insights
Streptococcus agalactiae, a cause of neonatal meningitis, can lead to severe invasive disease like necrotizing fasciitis and toxic shock syndrome in adults. Early intervention is crucial for patient outcomes.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Critical Care Medicine
Background:
- Streptococcus agalactiae (Group B Streptococcus) is a primary cause of meningitis and septicemia in neonates.
- Invasive infections by S. agalactiae are increasingly recognized in nonpregnant adults, particularly those with chronic conditions.
- Risk factors include chronic diseases and immunodeficiency, predisposing individuals to Group B Streptococcal disease.
Observation:
- This case report details a severe necrotizing fasciitis (NF) with streptococcal toxic shock-like syndrome (STSS).
- The patient was a 76-year-old diabetic with subcutaneous emphysema.
- The causative agent was identified as S. agalactiae, serotype V.
Findings:
- The patient experienced a fulminant course of necrotizing fasciitis and streptococcal toxic shock-like syndrome.
- S. agalactiae serotype V was identified as the pathogen responsible for the invasive infection.
- Subcutaneous emphysema was noted in the context of this severe invasive S. agalactiae infection.
Implications:
- Clinicians must maintain a high index of suspicion for invasive S. agalactiae infections in adults, especially those with risk factors like diabetes and subcutaneous emphysema.
- Prompt diagnosis and management, including early surgical intervention, antimicrobial therapy, and intensive care, are critical for improving outcomes in patients with NF and/or STSS.
- This case highlights the potential for S. agalactiae to cause life-threatening infections in the elderly population.
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