Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality of artificial intelligence-generated responses on pediatric celiac disease: Comparative assessment of Open AI ChatGPT and Google Gemini.

JPGN reports·2026
Same author

Eosinophilic Esophagitis Secondary to Sublingual Immunotherapy Using the Aeroallergen Timothy Grass Pollen Allergy Extract: A Case Report.

Cureus·2025
Same author

Efficacy of low FODMAP diet in pediatric patients with disorders of gut-brain interaction.

JPGN reports·2025
Same author

Optimizing the Use of Computed Tomography for Appendicitis Diagnosis in the Pediatric Emergency Department Through the Quality Improvement Methodology.

Cureus·2025
Same author

Anaphylaxis to cow's milk protein in a probiotic not detected by the electronic medical record.

JPGN reports·2024
Same author

Anemia secondary to copper deficiency in a child receiving gastrojejunal feeds: A case report.

JPGN reports·2024

Related Experiment Video

Updated: Jul 15, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Rotavirus causes hepatic transaminase elevation.

Jonathan E Teitelbaum1, Rima Daghistani

  • 1Pediatric Gastroenterology and Nutrition, The Children's Hospital at Monmouth Medical Center, Long Branch, New Jersey 07740, USA. jteitelbaum@sbhcs.com

Digestive Diseases and Sciences
|April 14, 2007
PubMed
Summary

Rotavirus gastroenteritis in children frequently causes elevated liver enzymes, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST). This indicates potential liver involvement beyond typical intestinal symptoms in pediatric rotavirus infections.

More Related Videos

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
08:55

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

Related Experiment Videos

Last Updated: Jul 15, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
08:55

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Infectious Diseases

Background:

  • Rotavirus is a primary cause of acute gastroenteritis in children.
  • While gastrointestinal symptoms like vomiting and diarrhea are common, rotavirus may also affect organs outside the GI tract.
  • Evidence suggests rotavirus infection can lead to liver injury.

Purpose of the Study:

  • To investigate the incidence of elevated hepatic transaminases in children diagnosed with rotavirus gastroenteritis.
  • To determine the frequency and pattern of liver enzyme abnormalities in pediatric rotavirus cases.

Main Methods:

  • Serum samples from children with rotavirus gastroenteritis (identified by stool antigen testing) were analyzed for liver function tests.
  • Tests included alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, total bilirubin, direct bilirubin, and CPK.
  • Patient charts were reviewed to exclude other causes of liver injury.

Main Results:

  • Of 75 patients with available serum, 15 (20%) showed elevated ALT and AST.
  • One patient exhibited elevations in ALT, AST, alkaline phosphatase, and bilirubin.
  • A significant proportion (71%) had AST elevation alone, and 4% had AST and alkaline phosphatase elevation.

Conclusions:

  • Rotavirus gastroenteritis commonly leads to elevated liver transaminases in children.
  • These findings highlight the potential for extraintestinal manifestations, specifically liver enzyme abnormalities, during rotavirus infection.
  • Routine monitoring of liver enzymes may be considered in pediatric rotavirus cases.