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Published on: August 15, 2016
[Preparation of inclusion complex of paeonol and beta-cyclodextrin by sealed-control temperature method]
Qi-fang Wang1, Xiao-wen Fan, Lu Xu
1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. oshwang@sina.com
Objective:
In the present study, using paeonol as model drug, a new sealed-control temperature method of preparing inclusion complex was developed, the effects of heating temperature, heating time, and crystallinity of beta-cyclodextrin (beta-CD) on formation of inclusion complex and release of the drug were investigated.
Method:
A physical mixture of paeonol and beta-CD was sealed in a container, and heated at the desired temperature for the specified time. The inclusion complex of paeonol and beta-CD was confirmed by IR spectrum and powder X-ray diffraction.
Result:
The results indicated that the inclusion complex formation of paeonol beta-CD by sealed-control temperature method was affected by heating temperature, heating time, and crystallinity of beta-CD. The inclusion complex was able to inhibit sublimation of paeonol, and dissolution rate of paeonol was increased when the paeonol was included by beta-CD.
Conclusion:
Preparation of inclusion complex was simple and quick by sealed-control temperature method.
