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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp
Tianying An1, Thallapuranam Krishnaswamy Suresh Kumar, Minglei Wang
1Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, USA.
Abstract:
The isolation and structure elucidation of two cyclic peptides, pahayokolides A (1) and B (2), is described. Structural features determined for these compounds include a pendent N-acetyl-N-methyl leucine, both E- and Z-dehydrobutyrines, a homophenylalanine, and an unusual polyhydroxy amino acid that is most likely of mixed polyketide synthase/nonribosomal peptide synthase origin. These peptides were purified from a new species of cyanobacteria of the genus Lyngbya, which was isolated from a periphyton mat from the Florida Everglades.
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