Comparison of urinary and recombinant human chorionic gonadotropin during ovulation induction in intrauterine insemination cycles: a prospective randomized clinical trial
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Published on: October 18, 2024
Khaled Sakhel1, Mohamed Khedr, Sandra Schwark
1Synergy Medical Education Alliance, Michigan State University, Saginaw, Michigan, USA.
Objectives:
To compare the in vivo effectiveness of recombinant (r) hCG with urinary (u) hCG during controlled ovarian hyperstimulation and intrauterine insemination (COH-IUI) cycles.
Design:
Prospective controlled clinical study.
Setting:
Private IVF center.
Patient(S):
Two hundred eighty-four subjects undergoing COH-IUI cycles.
Interventions(S):
Women were randomized into receiving r-hCG or u-hCG for final maturation and induction of ovulation.
Main Outcome Measure(S):
Clinical pregnancy rate and outcome of pregnancy.
Result(S):
Background characteristics were similar in the two groups studied except for a slight difference in the mean duration of infertility (3.0 vs. 2.3). There was no significant difference in the number of follicles > or =16 mm, mean peak E(2), or mean 1-week P levels between the two groups. The clinical pregnancy rate was 27.1% in the recombinant group compared with 28.5% in the urinary group. The outcome of pregnancy was similar in both groups.
Conclusion(S):
Recombinant hCG was found to be as effective as u-hCG in achieving pregnancy during COH-IUI cycles. This is in agreement with earlier studies on the effectiveness of r-hCG in IVF cycles.
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