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Updated: Jul 15, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Incidence of hyperthyroidism after unrelated donor allogeneic stem cell transplantation
Jolanta B Perz1, David Marin, Richard M Szydlo
1Department of Haematology, Hammersmith Hospital NHS Trust, Du Cane Road, W12 London, UK. jolanta@tjdengler.info
Abstract:
We report on three patients who developed overt thyrotoxicosis after volunteer unrelated donor bone marrow transplantation for Philadelphia chromosome positive chronic myeloid leukemia shortly after the onset of chronic graft versus host disease. In all three cases, the etiology of hyperthyroidism is likely to be a combination of toxic factors and an immune process. Systematic evaluation of thyroid function tests in 97 unrelated allograft recipients from our center who survived at least 100 days from stem cell or bone marrow transplantation for hematological diseases gave a rate of overt thyrotoxicosis at 3.1% in this cohort.
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