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Updated: Jul 15, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
Skin permeation of ketotifen applied from stick-type formulation
Chiharu Kimura1, Toshihiro Nakanishi, Kakuji Tojo
1College of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan.
Abstract:
A stick-typed long lasting device for both transdermal and topical drug delivery has been developed. Ketotifen fumarate (KT) was used as a model drug. The effect of a variety of permeation enhancers was investigated using hairless mouse skin in vitro. Polyoxyethylene oleyl ether (POE), among the enhancers used, most enhanced the skin permeation of KT. The permeation enhancement was mainly due to the increase in the drug solubility in the stratum corneum and the resulting increase in the partition coefficient. The rate of skin permeation of KT was approximately proportional to the loading dose of the drug.
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