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Paraoxonase, total antioxidant activity and peroxide levels in marasmic children: relationships with leptin

Aydin Ece1, Fuat Gürkan, Fatma Celik

  • 1Department of Pediatrics, Dicle University, Medical School, Diyarbakir, Turkey. aydece@dicle.edu.tr

Clinical Biochemistry
|April 17, 2007
PubMed

Insights

Children with marasmic malnutrition exhibit heightened oxidative stress and reduced antioxidant defenses. Nutritional rehabilitation may benefit from antioxidant supplementation to combat these imbalances.

Area of Science:

  • Biochemistry
  • Pediatric Nutrition
  • Oxidative Stress Research

Background:

  • Marasmic malnutrition is a severe form of undernutrition in children.
  • Oxidative stress, an imbalance between oxidants and antioxidants, is implicated in various health conditions.
  • Understanding the biochemical profile of malnourished children is crucial for effective treatment.

Purpose of the Study:

  • To investigate the oxidant/antioxidant status in children with marasmic malnutrition.
  • To assess paraoxonase (PON) activity and leptin levels in this population.
  • To explore correlations between these markers and malnutrition severity.

Main Methods:

  • A case-control study involving 30 marasmic children and 28 healthy controls.
  • Measurement of plasma paraoxonase (PON) activity.
  • Quantification of total antioxidant activity (TAO), total peroxide (TPX), and leptin levels.

Main Results:

  • Marasmic children showed significantly lower leptin, PON activity, and TAO compared to controls.
  • Elevated total peroxide (TPX) levels were observed in malnourished children.
  • Negative correlation between PON activity and TPX; positive correlation between TAO and BMI in patients.

Conclusions:

  • Marasmic malnutrition is associated with increased oxidative stress and decreased antioxidant capacity.
  • The severity of oxidative stress correlates with the extent of malnutrition.
  • Antioxidant supplementation is suggested as a potential therapeutic strategy during nutritional rehabilitation.
Abstract

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