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Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...

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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
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Cell-derived microparticles and complement activation in preeclampsia versus normal pregnancy.

E Biró1, C A R Lok, C E Hack

  • 1Department of Clinical Chemistry, F-1-219, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD, Amsterdam, The Netherlands. e.biro@amc.nl

Placenta
|April 17, 2007
PubMed
Summary

Complement activation on microparticles is not increased in preeclampsia. Preeclamptic women had more microparticles with C-reactive protein (CRP), but this did not trigger further complement activation.

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Area of Science:

  • Immunology
  • Obstetrics
  • Vascular Biology

Background:

  • Inflammation is key in preeclampsia-related vascular dysfunction.
  • The complement system is implicated in preeclampsia pathogenesis.
  • Microparticles may play a role in complement activation during pregnancy.

Purpose of the Study:

  • To determine if complement activation on microparticles is elevated in preeclampsia.
  • To compare microparticle-associated complement activation between preeclamptic and healthy pregnant women.

Main Methods:

  • Plasma microparticles from preeclamptic, healthy pregnant, and nonpregnant women were analyzed.
  • Flow cytometry assessed bound complement components (C1q, C4, C3) and activators (CRP, SAP, IgM, IgG).
  • Fluid-phase complement activation products were also measured.

Main Results:

  • No increased complement activation on microparticle surfaces in preeclamptic women.
  • Microparticles with bound C-reactive protein (CRP) were significantly higher in preeclamptic versus healthy pregnant women.
  • Bound CRP on microparticles did not correlate with increased classical pathway activation in preeclampsia.

Conclusions:

  • No evidence supports increased complement activation on microparticle surfaces in preeclampsia.
  • Elevated microparticles with bound CRP in preeclampsia are not linked to enhanced classical pathway activation.
  • Findings suggest a distinct role for CRP-associated microparticles in preeclampsia pathogenesis.