Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein aggregation in silico.

Troy Cellmer1, Dusan Bratko, John M Prausnitz

  • 1National Institutes of Health, Bethesda, MD 20892, USA.

Trends in Biotechnology
|April 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term mitapivat treatment is safe and efficacious in patients with sickle cell disease.

Blood. Red cells & iron·2026
Same author

Wettability of Two-Dimensional Carbon Allotropes from Molecular Simulations.

Molecules (Basel, Switzerland)·2025
Same author

Therapeutic potential of the latest oxygen affinity-modifying agent, GBT021601, for treating sickle cell disease is questionable.

British journal of haematology·2024
Same author

Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease.

Haematologica·2024
Same author

Reversible Surface Energy Storage in Molecular-Scale Porous Materials.

Molecules (Basel, Switzerland)·2024
Same author

In vivo measurement of RBC survival in patients with sickle cell disease before or after hematopoietic stem cell transplantation.

Blood advances·2024

Molecular simulation aids in understanding protein aggregation, a key challenge in biopharmaceutical manufacturing. This computational approach improves protein folding studies and therapeutic development.

Area of Science:

  • Biotechnology
  • Computational Biology
  • Protein Science

Background:

  • Protein aggregation poses significant challenges in manufacturing protein therapeutics, impacting purification and stability.
  • Advances in computational power have enabled molecular simulation to study protein misfolding and aggregation.

Purpose of the Study:

  • To review the successes of in silico protein aggregation studies.
  • To emphasize the application of these methods in biotechnology.
  • To identify future prospects and relevant problems in biotechnology amenable to molecular simulation.

Main Methods:

  • In silico molecular simulation techniques.
  • Review of computational studies on protein folding and aggregation.
  • Analysis of biotechnology-related applications.

Related Experiment Videos

Main Results:

  • Molecular simulation has proven successful in investigating protein misfolding and aggregation.
  • Significant progress has been made in applying these computational tools to biotechnology challenges.
  • Several areas within biotechnology can benefit from further molecular simulation studies.

Conclusions:

  • In silico molecular simulation is a valuable tool for addressing protein aggregation in biopharmaceutical development.
  • Continued advancement in computational methods will enhance understanding and mitigation of protein aggregation.
  • Future research should focus on applying molecular simulation to specific biotechnology-related problems to improve therapeutic manufacturing and stability.