Related Experiment Video
Updated: Jul 15, 2026

Bilayer Microfluidic Device for Combinatorial Plug Production
Published on: December 1, 2023
Combinatorial design of passive drug delivery platforms
Sébastien Casault1, Martin Kenward, Gary W Slater
1Department of Physics, University of Ottawa, 150 Louis-Pasteur, Ottawa, Ontario K1N 6N5, Canada.
Abstract:
We introduce a novel computational approach to designing passive drug delivery systems based on porous materials such as hydrogels. Our approach uses three tools: a method to establish the exact release pattern from all possible loading sites inside a given hydrogel; a method to generate a large number of hydrogel structures to be tested numerically, and finally an optimization algorithm which leads to the selection of optimal hydrogel structures. Using this approach, we show that controlled release curves can be obtained by using a genetic algorithm for the optimization step. Strategies to generalize this approach to other systems are also discussed.
Related Concept Videos
Modified-Release Drug Delivery Systems: Site-Targeted
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Rate-Programmed II
Drug Delivery Systems: Different Types
Biopharmaceutical Factors Influencing Drug Product Design: Overview
Modified-Release Drug Delivery Systems: Overview
