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Updated: Jul 15, 2026
07:10
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
Published on: April 21, 2019
Bioinformatics applied to allergy: allergen databases, from collecting sequence information to data integration. The
Adriano Mari1, Enrico Scala, Paola Palazzo
1Allergy Data Laboratories sc, Via Malipiero 28, 04100 Latina, Italy. adriano.mari@allergome.org
Cellular Immunology
|April 17, 2007
Summary
Allergens are proteins triggering allergic reactions. The Allergome platform offers a comprehensive, free resource for IgE-binding compounds, including data mining and literature review tools for allergy research.
Area of Science:
- Immunology
- Bioinformatics
- Allergy Research
Background:
- Allergens are proteins/glycoproteins recognized by IgE in allergic individuals.
- Approximately 1,500 allergenic structures identified, with ongoing discoveries.
- Various allergen databases exist with different focuses.
Purpose of the Study:
- To detail features of allergen-focused websites.
- To present the Allergome platform as an open resource for IgE-binding compounds.
- To introduce novel data mining and literature review tools for allergy research.
Main Methods:
- Development of the Allergome web server (www.allergome.org).
- Implementation of the Real Time Monitoring of IgE sensitization (ReTiME) module for raw data analysis.
- Integration of the RefArray module for literature mining.
Main Results:
- Allergome provides an exhaustive repository of allergenic sources and molecules.
- ReTiME enables IT application to allergy data mining from in vivo and in vitro tests.
- RefArray facilitates literature mining for allergy-related studies.
Conclusions:
- Allergome serves as a valuable, free, open-access resource for allergy research.
- The integrated modules (ReTiME, RefArray) enhance allergy data analysis and knowledge discovery.
- These advancements support the continued identification and understanding of allergenic compounds.
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