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Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis
Venil N Sumantran1, Asavari Kulkarni, Sanjay Boddul
1Interactive Research School for Health Affairs (IRSHA), Bhartiya Vidyapeeth Deemed University Medical College Campus, Dhankawadi, Pune 411043, India. vsumantran@gmail.com
Journal of Biosciences
|April 17, 2007
Abstract:
This is the first report describing two novel chondroprotective activities of aqueous extracts of Withania somnifera root powder.First,these extracts had a statistically significant,short-term chondroprotective effect on damaged human osteoarthritic cartilage matrix in 50% of the patients tested. Second,these extracts caused a significant and reproducible inhibition of the gelatinase activity of collagenase type 2 enzyme in vitro.