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Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
Influenza parotitis: a case from the 2004 to 2005 vaccine shortage
Steven Battle1, Joel Laudenbach, James H Maguire
1Department of Emergency Medicine, York Memorial Hospital, York, Pennsylvania, USA. stevenbattle@post.harvard.edu
Abstract:
We report a case of acute parotitis due to influenza A in which, unlike other published cases, the diagnosis was confirmed by demonstration of subtyped influenza A, serological evidence of mumps immunity, and full recovery without antibiotic treatment. In the United States, acute infectious parotitis was historically caused primarily by symptomatic paramyxovirus (mumps) infections, but because of the near-universal administration of the measles, mumps and rubella vaccine, other infectious and noninfectious etiologies now predominate. We discuss the differential diagnosis and therapeutic and public health considerations of parotitis and influenza. Due to time-sensitive pharmacologic management and possibly far-reaching public health issues, providers should be aware of atypical influenza presentations, such as parotitis.
Insights
Acute parotitis can be caused by influenza A, not just mumps. Early diagnosis of influenza A is crucial for timely treatment and public health, even with atypical presentations like parotitis.
Area of Science:
- Infectious Diseases
- Virology
- Public Health
Background:
- Acute infectious parotitis was historically attributed to mumps virus.
- Widespread measles, mumps, and rubella (MMR) vaccination has shifted parotitis etiologies.
- Non-mumps causes, including viral infections, are now more prevalent.
Observation:
- A case of acute parotitis confirmed as influenza A infection is presented.
- Diagnosis involved subtyping influenza A and serological confirmation of mumps immunity.
- The patient recovered fully without antibiotic intervention.
Findings:
- Influenza A can present as acute parotitis, mimicking mumps.
- Diagnostic confirmation requires specific viral identification and exclusion of other causes.
- Recovery was achieved without antibiotics, suggesting a self-limiting viral process.
Implications:
- Clinicians must consider influenza A in the differential diagnosis of acute parotitis.
- Awareness of atypical influenza presentations is vital for appropriate management.
- Timely diagnosis and treatment of influenza have significant public health implications.
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Influenza
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Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:

