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Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation
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ECT in a man with FG syndrome.

Christopher L Myers1, Stephen H Dinwiddie

  • 1University of Chicago Pritzker School of Medicine, Chicago, IL 60637-1470, USA.

The Journal of ECT
|April 17, 2007
PubMed
Summary

Electroconvulsive therapy (ECT) effectively reduced aggression in a young man with FG syndrome and schizophrenia, who had not responded to medications. This treatment led to a significant decrease in hospitalizations, allowing community maintenance.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • FG syndrome is a rare genetic disorder associated with intellectual disability and behavioral issues.
  • Schizophrenia is a chronic mental disorder characterized by psychosis, including thought disorder and aggression.
  • Pharmacological treatments for severe aggression and thought disorder in FG syndrome and schizophrenia can be ineffective.

Observation:

  • A 20-year-old male patient with FG syndrome and schizophrenia presented with refractory thought disorder and aggression.
  • The patient received 71 electroconvulsive therapy (ECT) treatments over 13 months.
  • Significant reduction in aggressive behavior was observed following ECT.

Findings:

  • ECT administration resulted in a marked decrease in the patient's aggressive behaviors.

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  • Hospitalization days decreased from 189 days in the 14 months prior to ECT to zero days in the 13 months following ECT.
  • The patient was successfully maintained in the community without psychiatric hospitalization after ECT.

    • Implications:

    • Electroconvulsive therapy may be a viable treatment option for managing severe aggression in individuals with FG syndrome and schizophrenia.
    • ECT can potentially reduce psychiatric hospitalizations and improve community functioning in complex psychiatric cases.
    • Further research is warranted to explore the efficacy and long-term outcomes of ECT in FG syndrome patients with psychiatric comorbidities.