A simple way to compute protein dynamics without a mechanical model
Related Experiment Video
Updated: Jul 15, 2026

Study of Protein Dynamics via Neutron Spin Echo Spectroscopy
Published on: April 13, 2022
Chien-Hua Shih1, Shao-Wei Huang, Shih-Chung Yen
1Institute of Bioinformatics, National Chiao Tung University, HsinChu 30050, Taiwan, Republic of China.
Abstract:
We found that in proteins the average atomic fluctuation is linearly related to the square of the atomic distance from the center of mass of the protein. Using this simple relation, we can accurately compute the temperature factors of proteins of a wide range of sizes and folds, and the correlation of the fluctuations in proteins. This simple relation provides a direct link between protein dynamics and the static protein's geometrical shape and offers a simple way to compute protein dynamics without either long time trajectory integration or any matrix operations.
Related Concept Videos
Mechanical Protein Functions
Protein Dynamics in Living Cells
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
Mechanical Protein Function
Physiological Pharmacokinetic Models: Assumption with Protein Binding
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Protein Diffusion in the Membrane
