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Updated: Jul 15, 2026
06:40
Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
Future of infertility treatment
Somjate Manipalviratn1, Andy Huang, Alan H Decherney
1Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
International Surgery
|April 18, 2007
Summary
Future fertility treatments aim to extend reproductive windows for women delaying childbearing. Innovations include oocyte rejuvenation and germ cell production, alongside advanced diagnostics and therapies for improved infertility treatment.
Area of Science:
- Reproductive medicine and biotechnology
- Genetics and molecular biology
- Obstetrics and gynecology
Background:
- Delayed childbearing is a growing trend, increasing the need for fertility preservation.
- Current methods like cryopreservation offer limited success in prolonging fertility.
- Understanding the molecular and genetic basis of infertility is crucial for effective treatment.
Purpose of the Study:
- To review current and future techniques for extending the fertile window in women.
- To explore novel approaches for managing infertility and improving reproductive outcomes.
- To highlight advancements in diagnostic and therapeutic strategies for infertility.
Main Methods:
- Review of existing literature on fertility preservation and assisted reproductive technologies.
- Discussion of emerging techniques such as oocyte rejuvenation and stem cell-derived germ cells.
- Analysis of advancements in molecular and genetic evaluation of gametes and embryos.
Main Results:
- Cryopreservation of embryos, oocytes, and ovarian tissue are current methods for fertility preservation.
- Future strategies include in vitro oocyte rejuvenation and generation of germ cells from embryonic stem cells.
- Molecular and genetic analysis offers deeper insights into infertility causes.
Conclusions:
- Technological advancements promise to significantly improve the convenience and effectiveness of infertility treatments.
- Future fertility solutions may enable women to achieve pregnancy with their own genetic offspring later in life.
- Personalized and precise treatments for infertility will become more attainable with enhanced understanding and technology.
Related Concept Videos
01:24In Vitro Fertilization
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
01:23Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
01:28Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...
01:38Fertilization
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
01:21Intrauterine Drug Delivery Systems
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01:22Birth Control Methods
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...