[Multiple lung metastasectomy for the poor differentiated metastatic synovial sarcoma]

Area of Science:

• Surgical Oncology
• Thoracic Surgery
• Sarcoma Research

Background:

• Synovial sarcoma, characterized by aggressive behavior and early metastasis, rarely necessitates pulmonary metastasectomy.
• Radical surgical intervention for multiple pulmonary metastases can enhance survival and quality of life in carefully selected patients.

Observation:

• A case study of a 39-year-old male with bilateral lung metastases from synovial sarcoma treated with complete metastasectomy.
• Pathological analysis revealed biphasic metastatic synovial sarcoma with high mitotic activity.
• The patient underwent six cycles of MAID chemotherapy following surgery.

Findings:

• The overall median survival for the group of seven patients was 25 months, with three patients still alive.
• The index patient remained disease-free 45 months post-lung metastasectomy, with a suspicious rib lesion later identified as reparative changes.
• Complete resection of lung metastases is a prerequisite for effective treatment.

Implications:

• Pulmonary metastasectomy is a valuable treatment for multiple synovial sarcoma lung metastases, despite uncertain long-term outcomes.
• Metastasectomy should be considered even for poorly differentiated tumors.
• Achieving complete tumor resection is paramount for successful patient outcomes.